molecular formula Ca B576841 Calcium-46 CAS No. 13981-77-6

Calcium-46

Cat. No.: B576841
CAS No.: 13981-77-6
M. Wt: 45.954
InChI Key: OYPRJOBELJOOCE-LZFNBGRKSA-N
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Description

Calcium-46 is a stable isotope of calcium with an atomic number of 20 and a mass number of 46. It is one of the less abundant isotopes of calcium, constituting about 0.004% of natural calcium . This compound is notable for its stability and its role in various scientific research applications, particularly in the fields of geology, biology, and medicine.

Mechanism of Action

Calcium plays a vital role in the anatomy, physiology, and biochemistry of organisms and of the cell, particularly in signal transduction pathways . It is vital in cell signaling, muscular contractions, bone health, and signaling cascades .

Safety and Hazards

When handling Calcium-46, it is advised to wear personal protective equipment, avoid contact with skin, eyes, and clothing, and not to ingest or breathe dust . In case of a fire, fight it with normal precautions from a reasonable distance and wear a self-contained breathing apparatus .

Future Directions

Calcium-46, as a stable isotope of calcium, has potential applications in various fields. For instance, in the medical field, calcium scores obtained from CT scans have been shown to be prognostic in the assessment of the risk for the development of cardiovascular diseases .

Preparation Methods

Synthetic Routes and Reaction Conditions: Calcium-46 can be produced through the neutron activation of calcium-45 or by the separation of isotopes using mass spectrometry techniques . The process involves irradiating calcium-45 with neutrons, which converts it into this compound.

Industrial Production Methods: Industrial production of this compound typically involves the use of high-purity calcium sources and advanced separation techniques such as thermal ionization mass spectrometry (TIMS) and accelerator mass spectrometry (AMS) . These methods ensure the precise separation and enrichment of this compound from other isotopes.

Chemical Reactions Analysis

Types of Reactions: Calcium-46, like other calcium isotopes, undergoes various chemical reactions, including:

Common Reagents and Conditions:

Major Products:

Comparison with Similar Compounds

    Calcium-40: The most abundant

Properties

IUPAC Name

calcium-46
Source PubChem
URL https://pubchem.ncbi.nlm.nih.gov
Description Data deposited in or computed by PubChem

InChI

InChI=1S/Ca/i1+6
Source PubChem
URL https://pubchem.ncbi.nlm.nih.gov
Description Data deposited in or computed by PubChem

InChI Key

OYPRJOBELJOOCE-LZFNBGRKSA-N
Source PubChem
URL https://pubchem.ncbi.nlm.nih.gov
Description Data deposited in or computed by PubChem

Canonical SMILES

[Ca]
Source PubChem
URL https://pubchem.ncbi.nlm.nih.gov
Description Data deposited in or computed by PubChem

Isomeric SMILES

[46Ca]
Source PubChem
URL https://pubchem.ncbi.nlm.nih.gov
Description Data deposited in or computed by PubChem

Molecular Formula

Ca
Source PubChem
URL https://pubchem.ncbi.nlm.nih.gov
Description Data deposited in or computed by PubChem

Molecular Weight

45.95369 g/mol
Source PubChem
URL https://pubchem.ncbi.nlm.nih.gov
Description Data deposited in or computed by PubChem

CAS No.

13981-77-6
Record name Calcium, isotope of mass 46
Source ChemIDplus
URL https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0013981776
Description ChemIDplus is a free, web search system that provides access to the structure and nomenclature authority files used for the identification of chemical substances cited in National Library of Medicine (NLM) databases, including the TOXNET system.

Synthesis routes and methods I

Procedure details

10 kg batches of sodium perborate were treated in a series of experiments with CaCl2 in a two-stage spray process using in the first stage 1.5 kg of 30% by weight CaCl2 solution and in the second stage 1.5 kg of water, giving a perborate having a calcium content of 1.6% by weight.
Quantity
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reactant
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reactant
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1.5 kg
Type
reactant
Reaction Step Three
Name
perborate
Name
calcium

Synthesis routes and methods II

Procedure details

Another aspect of the invention includes an injectible paste having a mixture of a reactive amorphous calcium phosphate powder, the amorphous calcium phosphate having a calcium to phosphorous atomic ratio in the range of about 1.55 to 1.70, and alternatively about 1.55 to 1.65, and alternatively 1.55 to 1.6, and reactive vacant sites, and a second calcium phosphate powder, and an amount of water sufficient to provide the desired consistency. The water is buffered to a physiologically acceptable pH. The paste is hardenable at body temperature.
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solvent
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calcium
Name
phosphorous
Name
calcium phosphate

Synthesis routes and methods III

Procedure details

The inventors have discovered that simple admixture or combination of L-carnitine, a calcium or magnesium salt, and valproic acid without a suitable solvent is not sufficient to provide an L-carnitine valproate salt of the present invention. After simple admixture or combination without a suitable solvent, L-carnitine retains its objectionable malodor and offensive taste, as well as its hygroscopicity, and valproic acid remains an oil. In contrast, use of the methods of preparing the L-carnitine valproate salt of the present invention as disclosed herein provides a composition of the present invention that is free from objectionable taste and free or nearly free from repugnant odor. Further, an L-carnitine valproate salt of the present invention has different physico-chemical properties from the starting materials. As we discovered and disclose in Example 1, for example, L-carnitine calcium valproate, an embodiment of the present invention, has a melting point of 171.2° C., different from the melting point of L-carnitine (186-190° C.) or valproic acid (an oil at room temperature and above). The 1H-NMR spectrum of L-carnitine calcium valproate (FIG. 2) differs from that of the starting materials (i.e., L-carnitine and valproic acid) and confirms the structure. L-carnitine calcium valproate is soluble in water, and aqueous solutions of this salt provide bioavailable L-carnitine, calcium, and valproate.
Name
L-carnitine calcium valproate
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L-carnitine
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Reaction Step Three
Name
L-carnitine calcium valproate
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Reaction Step Four
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solvent
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L-carnitine
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Reaction Step Seven
[Compound]
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L-carnitine valproate salt
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Reaction Step Eight
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L-carnitine valproate salt
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L-carnitine calcium valproate
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Name
L-carnitine
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0 (± 1) mol
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Reaction Step Eleven
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0 (± 1) mol
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reactant
Reaction Step Eleven
Name
L-carnitine
Name
calcium
Name
valproate

Synthesis routes and methods IV

Procedure details

Eggshell powder is used in the food industry, including animal and human nutritional supplements. Eggshells provide approximately 36-37 percent elemental calcium in addition to traces of phosphorous and other trace elements. Thus, for example, 500 mg of dried powdered eggshell provides approximately 180 mg elemental calcium. This compared vary favorably to other calcium salts. For example, calcium carbonate provides 40 percent elemental calcium, calcium citrate provides 21 percent elemental calcium, calcium lactate provides 13 percent elemental calcium, calcium gluconate provides 9 percent elemental calcium, dicalcium phosphate provides 23 percent elemental calcium (and 19 percent phosphorus), and bone meal provides 20 percent elemental calcium (and 17 percent phosphorus). A single large eggshell has a mass of approximately 6 g and provides approximately 2200 mg of calcium.
Quantity
0 (± 1) mol
Type
reactant
Reaction Step One
Name
calcium
Quantity
180 mg
Type
reactant
Reaction Step Two
[Compound]
Name
calcium salts
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reactant
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calcium
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Reaction Step Five
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Type
reactant
Reaction Step Six
Name
calcium
Yield
21%
Name
calcium lactate

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