molecular formula Ca B076470 Calcium-40 CAS No. 14092-94-5

Calcium-40

Cat. No.: B076470
CAS No.: 14092-94-5
M. Wt: 39.962591 g/mol
InChI Key: OYPRJOBELJOOCE-IGMARMGPSA-N
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Scientific Research Applications

Calcium-40 has a wide range of applications in scientific research:

Mechanism of Action

Calcium plays a vital role in the anatomy, physiology, and biochemistry of organisms and of the cell, particularly in signal transduction pathways . More than 500 human proteins are known to bind or transport calcium .

Safety and Hazards

Calcium-40, like other forms of calcium, should be handled with care. Personal protective equipment/face protection should be worn, and adequate ventilation should be ensured . It should not get in eyes, on skin, or on clothing, and ingestion and inhalation should be avoided .

Preparation Methods

Synthetic Routes and Reaction Conditions: Calcium-40 can be isolated from natural calcium sources through isotope separation techniques. One common method is the use of mass spectrometry, which separates isotopes based on their mass-to-charge ratio. Another method involves chemical processes that exploit slight differences in the chemical behavior of calcium isotopes.

Industrial Production Methods: In industrial settings, this compound is typically obtained through the fractional distillation of calcium compounds. This process involves converting calcium compounds into a gaseous state and then separating the isotopes based on their boiling points. The production of this compound is often carried out in specialized facilities equipped with advanced separation technologies.

Types of Reactions:

    Oxidation: this compound reacts with oxygen to form calcium oxide (CaO). This reaction is exothermic and occurs readily at elevated temperatures. [ 2 \text{Ca} + \text{O}_2 \rightarrow 2 \text{CaO} ]

    Reduction: this compound can be reduced from its compounds using strong reducing agents like sodium or magnesium.

    Substitution: this compound can undergo substitution reactions with halogens to form calcium halides, such as calcium chloride (CaCl₂). [ \text{Ca} + \text{Cl}_2 \rightarrow \text{CaCl}_2 ]

Common Reagents and Conditions:

    Oxygen: Used in oxidation reactions to form calcium oxide.

    Halogens: Used in substitution reactions to form calcium halides.

    Strong Reducing Agents: Used in reduction reactions to isolate calcium from its compounds.

Major Products:

    Calcium Oxide (CaO): Formed from oxidation reactions.

    Calcium Halides (e.g., CaCl₂): Formed from substitution reactions.

Comparison with Similar Compounds

  • Calcium-42
  • Calcium-43
  • Calcium-44
  • Calcium-46
  • Calcium-48

Comparison: Calcium-40 is unique due to its high natural abundance and stability. Unlike some other calcium isotopes, such as calcium-41, which is radioactive, this compound does not undergo radioactive decay, making it more suitable for long-term studies and applications. Additionally, this compound’s stable nature allows it to be used in a wide range of scientific and industrial applications without the concerns associated with radioactivity .

Properties

IUPAC Name

calcium-40
Source PubChem
URL https://pubchem.ncbi.nlm.nih.gov
Description Data deposited in or computed by PubChem

InChI

InChI=1S/Ca/i1+0
Source PubChem
URL https://pubchem.ncbi.nlm.nih.gov
Description Data deposited in or computed by PubChem

InChI Key

OYPRJOBELJOOCE-IGMARMGPSA-N
Source PubChem
URL https://pubchem.ncbi.nlm.nih.gov
Description Data deposited in or computed by PubChem

Canonical SMILES

[Ca]
Source PubChem
URL https://pubchem.ncbi.nlm.nih.gov
Description Data deposited in or computed by PubChem

Isomeric SMILES

[40Ca]
Source PubChem
URL https://pubchem.ncbi.nlm.nih.gov
Description Data deposited in or computed by PubChem

Molecular Formula

Ca
Source PubChem
URL https://pubchem.ncbi.nlm.nih.gov
Description Data deposited in or computed by PubChem

DSSTOX Substance ID

DTXSID50161493
Record name Calcium, isotope of mass 40
Source EPA DSSTox
URL https://comptox.epa.gov/dashboard/DTXSID50161493
Description DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.

Molecular Weight

39.9625908 g/mol
Source PubChem
URL https://pubchem.ncbi.nlm.nih.gov
Description Data deposited in or computed by PubChem

CAS No.

14092-94-5
Record name Calcium, isotope of mass 40
Source ChemIDplus
URL https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0014092945
Description ChemIDplus is a free, web search system that provides access to the structure and nomenclature authority files used for the identification of chemical substances cited in National Library of Medicine (NLM) databases, including the TOXNET system.
Record name Calcium, isotope of mass 40
Source EPA DSSTox
URL https://comptox.epa.gov/dashboard/DTXSID50161493
Description DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.

Synthesis routes and methods I

Procedure details

10 kg batches of sodium perborate were treated in a series of experiments with CaCl2 in a two-stage spray process using in the first stage 1.5 kg of 30% by weight CaCl2 solution and in the second stage 1.5 kg of water, giving a perborate having a calcium content of 1.6% by weight.
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1.5 kg
Type
reactant
Reaction Step Three
Name
perborate
Name
calcium

Synthesis routes and methods II

Procedure details

Another aspect of the invention includes an injectible paste having a mixture of a reactive amorphous calcium phosphate powder, the amorphous calcium phosphate having a calcium to phosphorous atomic ratio in the range of about 1.55 to 1.70, and alternatively about 1.55 to 1.65, and alternatively 1.55 to 1.6, and reactive vacant sites, and a second calcium phosphate powder, and an amount of water sufficient to provide the desired consistency. The water is buffered to a physiologically acceptable pH. The paste is hardenable at body temperature.
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solvent
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calcium
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phosphorous
Name
calcium phosphate

Synthesis routes and methods III

Procedure details

The inventors have discovered that simple admixture or combination of L-carnitine, a calcium or magnesium salt, and valproic acid without a suitable solvent is not sufficient to provide an L-carnitine valproate salt of the present invention. After simple admixture or combination without a suitable solvent, L-carnitine retains its objectionable malodor and offensive taste, as well as its hygroscopicity, and valproic acid remains an oil. In contrast, use of the methods of preparing the L-carnitine valproate salt of the present invention as disclosed herein provides a composition of the present invention that is free from objectionable taste and free or nearly free from repugnant odor. Further, an L-carnitine valproate salt of the present invention has different physico-chemical properties from the starting materials. As we discovered and disclose in Example 1, for example, L-carnitine calcium valproate, an embodiment of the present invention, has a melting point of 171.2° C., different from the melting point of L-carnitine (186-190° C.) or valproic acid (an oil at room temperature and above). The 1H-NMR spectrum of L-carnitine calcium valproate (FIG. 2) differs from that of the starting materials (i.e., L-carnitine and valproic acid) and confirms the structure. L-carnitine calcium valproate is soluble in water, and aqueous solutions of this salt provide bioavailable L-carnitine, calcium, and valproate.
Name
L-carnitine calcium valproate
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L-carnitine
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Name
L-carnitine calcium valproate
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L-carnitine
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L-carnitine valproate salt
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L-carnitine valproate salt
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L-carnitine calcium valproate
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L-carnitine
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reactant
Reaction Step Eleven
Name
L-carnitine
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calcium
Name
valproate

Synthesis routes and methods IV

Procedure details

Eggshell powder is used in the food industry, including animal and human nutritional supplements. Eggshells provide approximately 36-37 percent elemental calcium in addition to traces of phosphorous and other trace elements. Thus, for example, 500 mg of dried powdered eggshell provides approximately 180 mg elemental calcium. This compared vary favorably to other calcium salts. For example, calcium carbonate provides 40 percent elemental calcium, calcium citrate provides 21 percent elemental calcium, calcium lactate provides 13 percent elemental calcium, calcium gluconate provides 9 percent elemental calcium, dicalcium phosphate provides 23 percent elemental calcium (and 19 percent phosphorus), and bone meal provides 20 percent elemental calcium (and 17 percent phosphorus). A single large eggshell has a mass of approximately 6 g and provides approximately 2200 mg of calcium.
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0 (± 1) mol
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reactant
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calcium
Quantity
180 mg
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reactant
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Name
calcium salts
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calcium
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Name
calcium
Yield
21%
Name
calcium lactate

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